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5. Pseudo-proteoglycan |
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We develop glycan probe to use for research and medical treatment by investigating the function of glycan. Pseudo-proteoglycan (pseudo-PG) is man-made complex molecule that we created by modeling after the molecular structure of natural proteoglycan and having direct-chained high molecule joint-interact to various glycosaminoglycan (GAG). Based on the new structure, we found out that pseudo-PG shows different binding activation from independent GAG chain against GAG binding protein such as Cyclophilin A. we aim at the structural characteristic and remarkable binding specificity of pseudo-PG, and we try to use it for blocking the mechanism of initial infection of HIV-1 virus which needs proteoglycan above cell membranes and as an infectious inhibitor which also has an effect on recovery of resistance against HIV-1. We are now supported research expenses by the Ministry of Health, Labor, and Welfare and developing joint research about anti-AIDS activation and molecular structure of pseudo-proteoglycan prove that has the structure simulated natural proteoglycan. 1) Nakagawa, K., et al. (2009) Pseudoproteoglycan (pseudoPG) probes that simulate PG macromolecular structure for screening and isolation of PG-binding proteins. Glycoconj. J., in press |
